Cardiac Remodeling or Ventricular Remodeling
It defines as genome expression resulting in molecular, cellular and interstitial changes and manifested clinically as changes in shape, structure, size, and function of the heart. Cardiac remodeling can happen as a result physiological remodelling or pathological remodeling (injury to the heart muscle) and from cardiac load or injury, cardiac remodeling is influenced by hemodynamic load, neurohormonal activation. Congenital heart disease, chronic hypertension, with intra-cardiac shunting, and valvular heart disease may also lead to remodeling. Mostly the cardiac myocyte is the major cell involved in cardiac remodeling. Due to this, the myocardial necrosis (cell death) and disproportionate thinning of the heart occurs.